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Examplify Pharmacology Exam-2 Section-2
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Hint : ⏰Think about giving the antibiotic when the binding resin is not yet present in the gut.

Correct Answers:

  • One hour before the cholestyramine


Rationale :

😊Cholestyramine is a bile acid sequestrant that binds many orally administered drugs in the gut, which can significantly reduce their absorption.

🧠To avoid this interaction, other oral medications, such as antibiotics, should be given at least 1 hour before the cholestyramine so they can be absorbed prior to the resin binding.

💊Administering the antibiotic one hour before allows adequate time for gastric emptying and intestinal absorption, maximizing the therapeutic effect of the antibiotic.

📚This timing strategy is a standard pharmacokinetic precaution used with binding resins to prevent treatment failure from decreased drug levels.

📌Core Message

Proper timing with cholestyramine means giving other oral drugs, like antibiotics, before the resin so their absorption and effectiveness are not reduced.

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