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Sweat chloride test
🧪The sweat chloride test is the gold standard diagnostic test used to confirm cystic fibrosis (CF).
🩺This test measures the amount of chloride in the child's sweat, which is typically elevated in individuals with CF due to a mutation in the CFTR gene that disrupts normal chloride transport.
📈A sweat chloride level of ≥60 mmol/L on two separate occasions is considered positive and confirms the diagnosis in the presence of clinical symptoms.
🔬Other tests like stool fat content analysis, sputum cultures, or pulmonary function tests may support the diagnosis or help monitor the disease but do not confirm it definitively.
📌Core Message
The sweat chloride test confirms cystic fibrosis by detecting abnormally high chloride levels in sweat, which reflect defective chloride transport.
This question is from ATI Pediatrics unit 2 Exam which contains 59 questions.
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