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Creatinine level
🧪Metformin is renally cleared, so renal function (e.g., creatinine/eGFR) must be verified to reduce lactic acidosis risk.
⚠️Impaired kidneys lead to drug accumulation, increasing the chance of metabolic acidosis, a rare but serious effect.
📋Electrolytes like potassium and counts like platelets do not predict metformin safety as directly as renal indices.
🩺Baseline creatinine/eGFR guides safe initiation, dose selection, or avoidance if eGFR <30 mL/min/1.73 m².
📌Core Message
Because metformin depends on renal clearance, verifying creatinine/eGFR first helps prevent lactic acidosis and ensures safe dosing.
This question is from RN ATI Pharmacology 2019 Exam-1 which contains 41 questions.
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